HOTAIR and Familial prostate cancer: There are some reports indicating the association between HOTAIR rs12826786 SNP which is located between HOTAIR and HOXC12. The increased risk for some cancers such as breast (BC) (Bayram et al., 2016), gastric adenocarcinoma (GCA) (Guo et al., 2015), prostate cancer (PC), and benign prostate hyperplasia (BPH) (Taheri et al., 2017) has been reported.