Furthermore, a study of 14,492 distinct solid tumors (primaries and metastases) with at least 30 per tumor type revealed that a 12-chemokine expression signature (CCL2, CCL3, CCL4, CCL5, CCL8, CCL18, CCL19, CCL21, CXCL9, CXCL10, CXCL11, and CXCL13) correlated with the presence of tertiary lymph node-like structures and was also associated with better overall survival of the subset of melanoma patients (76). This evidence concerns the gene CCL2 and neoplasm.