CD274 and neoplasm: Furthermore, Benci et al. showed that prolonged IFNγ signaling contributes to tumor growth as a result of expression of interferon-driven inhibitor ligands (IDILS) which, in addition to PD-L1, include TNF Receptor Superfamily Member 14/Herpes Virus Entry Mediator (TNFRSF14), galectin-9 (LGALS9), MHCII, CD28 Antigen Ligand 2/B7-2 (CD86), and the Interferon Stimulated genes (ISGs), such as Interferon-Induced Protein with Tetratricopeptide Repeats 1 (IFIT1) and MX Dynamin Like GTPase1 (MX1)(129).