TNF and colitis: Their adoptive transfer modulated the course of DSS colitis by enhancing the early (4 days) colonic mucosal expression of inflammatory cytokines Tnfα, Il1β, Il4, and Il12a, and the subsequent increase in Il6 and Il17a. Collectively, these data strongly suggest that DAB2 is downregulated in the course of experimental colitis and that its loss modulates mucosal dendritic cell function and promotes local inflammatory responses.