In contrast to these promising results, G-CSF treatment for 5 consecutive days or G-CSF treatment followed by 3 doses of autologous CD133+ hematopoietic stem cells in patients with compensated cirrhosis did not improve liver disease severity (MELD score, the primary outcome), and there was evidence to suggest G-CSF treatment, with or without stem cells, was associated with an increased frequency of adverse events compared to standard care (n = 26–28 per group) (121). The gene discussed is CSF3; the disease is liver disorder.