SERPINA1 and cancer: In contrast, CAAP48, as well as several variants of this C-terminal AAT-fragment [e.g., C-36 peptide, virus inhibitory peptide (VIRIP), cancer-associated, SCM-recognition, immune defense-suppressing, and serine protease-protecting (CRISPP) peptide, short piece of alpha 1-antitrypsin (SPAAT)] associated with certain pathological conditions, have pro-inflammatory immune modulating functions (4–8).