Again, mice injected with NFAT5 siRNAs showed reduced streptozotocin-induced diabetic retinopathy (61), suggesting that transcriptional knockdown of NFAT5 using siRNAs can be a useful strategy to treat NFAT5-dependent autoimmune inflammatory diseases including RA and diabetes mellitus. The gene discussed is NFAT5; the disease is rheumatoid arthritis.