Genetic loss PTH/PTHrP receptor (PTH1R) in mesenchymal stem cells using the paired related homeobox transcription factor 1 (Prx1)-Cre driver was reported to induce marrow adipogenesis, while PTH administration reduced marrow fat in mice and male patients with idiopathic osteoporosis, suggesting that PTH inhibits the differentiation of adipocyte progenitors to the adipocyte lineage (19). This evidence concerns the gene PTH and idiopathic juvenile osteoporosis.