ChIP assays performed in the breast cancer cell line MCF7 indicated that the promoter regions of 16 potential tumor suppressor genes were bound by OGT and were enriched in EZH2 and H3K27me3 in an OGT-dependent manner (48), also arguing for a role of O-GlcNAcylation in the regulation of the PRC2-mediated repression in the context of cancer. The gene discussed is OGT; the disease is cancer.