Lipid caused a reduction in the insulin stimulated glucose disposal rate in PCOS from 3.25 ± 0.76 to 1.14 ± 0.78 mg/kg/min, p = 1.9 × 10−7, and in controls from 4.8 ± 1.64 to 2.5 ± 1.54 mg/kg/min, p = 5.4 × 10−4 (Supplementary Table 2). The gene discussed is INS; the disease is polycystic ovary syndrome.