Subjects with PCOS had a significantly larger waist hip ratio (p = 0.02), higher FAI (p = 2.1 × 10−3), and HOMA-IR (p = 0.04), as well as lower HDL-c, and sex hormone binding globulin (SHBG) (p = 3.2 × 10−3) than controls. The gene discussed is SHBG; the disease is polycystic ovary syndrome.