This study showed no variants significantly associated with overall risk of prostate cancer, however in all cohorts was observed that variation in the CRY1 gene was associated with mortality in prostate cancer This study of individual cohorts revealed that two polymorphisms from CRY1, rs7297614, and rs1921126 were associated to increased mortality in 2 out 3 prostate cancer cohorts, and a similar association was proved for rs12315175 in the CRY1 gene in a single cohort. The gene discussed is CRY1; the disease is Familial prostate cancer.