In this multicenter, randomized, double-blind, and placebo-controlled prospective trial, we find that co-administration of 1.5 g LWDH and 24 mg Ginkgo biloba three times per day for 24 months is benefit to type 2 diabetes for microalbuminuria (as reflected by measures in UACR), associated with downregulation of inflammatory markers (i.e., fractalkine, AGE-P). This evidence concerns the gene CX3CL1 and type 2 diabetes mellitus.