A study of 70 pregnant women who had undergone preterm labor showed that the chorioamniotic membranes from those with acute histological chorioamnionitis compared to those without, had greater mRNA levels of inflammasome components, including NLRP3, and other NLR proteins, caspase 1, IL-1β, IL-18, and increased ASC and caspase 1 complex formation (Gomez-Lopez et al., 2017). This evidence concerns the gene CASP1 and chorioamnionitis.