Previous studies have demonstrated that the development of CD4+Teff cells, such as Th2 and Th17 cells, strongly contribute to airway inflammation, mucus production, AHR, and airway remodeling concomitant with high circulating levels of IgE in patients with allergic asthma (Zuska-Prot and Maslanka, 2017). Here, IGHE is linked to allergic asthma.