In vitro and in vivo studies indicate that, in breast cancer, Notch signaling activation leads to increased glycolysis through the activation of the PI3K/AKT pathway, resulting in the upregulation of GLUT1 expression and genes for rate-limiting glycolytic enzymes such as HK2, ALDOA and PDK2. Notch activation also induces GLUT1 translocation from cytoplasmic to membrane localization consistently with an increased glucose uptake due to glycolytic switch (Landor et al., 2011). The gene discussed is HK2; the disease is breast cancer.