We used human MM cell lines, primary MM patients’ cells and a zebrafish MM model to show that MM cell-derived Jagged1 and 2 are pivotal to promote tumor cell ability to reprogram the nearby BM niche, and specifically to trigger BMSCs to protect MM cells from apoptosis induced by bortezomib, lenalidomide, and melphalan (Garavelli et al., 2017). This evidence concerns the gene JAG1 and Miyoshi myopathy.