BIRC5 and Miyoshi myopathy: In MM cells IL-6 activates STAT3 signaling and increases the expression of antiapoptotic genes, such as Bcl2, Bcl-XL, Mcl-1, and survivin, commonly associated with chemoresistance (Catlett-Falcone et al., 1999; Shain et al., 2009; Ara and Declerck, 2010).