Similarly, primary marrow fat cells and adipocyte cell lines trigger metabolic reprogramming of bone metastatic prostate cancer cells by enhancing the expression of PDK1, enolase 2 (ENO2), LDHA as well as HK2 and GLUT1 (Diedrich et al., 2016), already mentioned as Notch downstream effectors in breast cancer cells (Landor et al., 2011). The gene discussed is LDHA; the disease is breast cancer.