LDHA and cancer: In OS, Notch activation is associated with the expression of a CSCs marker, ALDH (Mu et al., 2013), whose detoxifying activity promotes cancer cell drug resistance (Honoki et al., 2010); while miR-26a inhibits CSC self-renewal ability and promotes chemosensitivity by suppressing Jagged1/Notch signaling (Lu J. et al., 2017).