To determine whether COX2-PGD2 induced T2DM brain injury by affecting p-AKT(S473) and p-AMPK(T172) to inhibit autophagy and reduce the clearance of Aβ, we used WB to detect the related protein expression in the rat’s cortex and hippocampus. The gene discussed is AKT1; the disease is type 2 diabetes mellitus.