CLU and neurodegenerative disease: Increased levels of clusterin have been observed not only in the AD brain but also in other neurodegenerative diseases, including ALS (Grewal et al., 1999), multiple sclerosis (Ingram et al., 2014), transmissible spongiform encephalopathies (Sasaki et al., 2002a), and Huntington’s disease (Labadorf et al., 2015).