However, increased clusterin levels are also found in non-proteotoxic neurological diseases, including schizophrenia, Rett syndrome and hypoxia-ischaemia, all of which share at least some underlying pathogenic processes with those found in AD, clearly indicating that the role of secreted clusterin in AD may be more complex than just that of a chaperone. The gene discussed is CLU; the disease is schizophrenia.