APOE and amyloidosis: These findings suggest that clusterin and APOE may work cooperatively in this mouse model to reduce amyloid deposition and illustrate the complexity of understanding Aβ-clusterin interactions in vivo. A more recent study in APP/PS1 mice showed that CLU-KO shifts deposition of Aβ from plaques to accumulation in the cerebrovasculature, resulting in increased amyloid angiopathy but, surprisingly, reduced hemorrhage and inflammation (Wojtas et al., 2017).