Hypermethylated genes expressed at low levels demonstrated enrichment in arrhythmogenic right ventricular cardiomyopathy (ARVC), focal adhesion, hypertrophic cardiomyopathy (HCM), dilated cardiomyopathy, and PI3K-Akt signalling pathways (Table 2). The gene discussed is AKT1; the disease is arrhythmogenic right ventricular cardiomyopathy.