A GCN was established based on these 34 candidates, and eight sub-networks related to immune function were found using GCNA, which consisted of two candidate genes, LST1 and IGHM, and six co-expressed genes, IGHA1, IGHD, IGHG1, IGHG3, IGLC2, and IGLJ3. Studies have found the functional pathways of significant recurrent genes in BC to be associated with the immune response and sensitivity to drugs2 indicating that the immune-related genes identified in this study may also be related to drug sensitivity. This evidence concerns the gene IGHD and breast cancer.