Utilizing 3–4 month-old APP/PS1 mice (young APP/PS1 mice) that don’t show any amyloid plaques or cognitive deficit at this age19 and wild-type (WT) littermates, we first investigated the molecular pathway sensitive to sleep loss and examined the influence of sleep loss on hippocampal electrophysiological properties of both genotypes. The gene discussed is APP; the disease is Cognitive impairment.