GJB2 and atrial fibrillation: However, application of the gnomAD and ExAC filtering AF to 74 reported variants with unexpectedly high observed AFs (i.e., over our AF thresholds) allowed us to safely consider 47 variants with still high filtering AFs as not likely NSHL-related, with the notorious exception of one variant (GJB2 c.109G > A; p.Val37Ile)23.