Compared with non-obese men and women with the lowest CRP tertile, the multivariable HRs for risk of incident T2DM among obese men and women with the highest CRP tertile was 2.52 (1.44–4.12) in men and 4.74 (2.43–9.23) in women (p for trend <0.0001, p for interaction <0.01). This evidence concerns the gene CRP and type 2 diabetes mellitus.