By contrast, the LACC1/FAMIN variant was classified as pathogenic, as it is a null variant (a frameshift 2-bp deletion) that leads to a much shorter open reading frame (p.Cys43Tyrfs*6) (Fig. 1C), it is absent in public databases and in the group of healthy Moroccan controls, and the LACC1/FAMIN gene has been linked to various arthritis related phenotypes. This evidence concerns the gene LACC1 and arthritic joint disease.