GATA6 and cancer: Interestingly, all GATA family members besides GATA3 were mostly downregulated in most kinds of cancers, with upregulated vs downregulated study numbers (GATA1 1:7; GATA2 6:39; GATA3 31:36; GATA4 5:18; GATA5 1:17; GATA6 16:37).