In the discovery study, NfL was significantly regulated in plasma from B-ALS compared to L-ALS (logFC = −0.49 p-value = 0.008), whereas NfH did not show any significant regulation between B-ALS and L-ALS (logFC = 0.16 p-value = 0.13). The gene discussed is NEFH; the disease is amyotrophic lateral sclerosis.