The following pathways were among the top 20 regulated pathways in both PBMCs and plasma/brain proteomic studies: immunoregulatory interactions between a lymphoid and a non-lymphoid cell, regulation of actin cytoskeleton, RHO GTPases activation of CIT, RHO GTPases activation of PAKs, RHO GTPases activation of ROCKs, salmonella infection, Sema4D in semaphorin signalling, Sema4D induced cell migration and growth-cone collapse and semaphorin interactions (Table 4). The gene discussed is CIT; the disease is Salmonella Infections.