Classical GBM patients in the TCGA dataset with CHD4 mRNA expression in the highest quartile (n = 50) have a significantly lower median survival (12.9 months) than patients with CHD4 mRNA expression in the lowest quartile (n = 51; 15.7 months), p = 0.0231 (Fig. 1d); these results did not change when we excluded patients with the glioma-CpG island methylator phenotype (G-CIMP) (n = 2). This evidence concerns the gene CHD4 and central nervous system cancer.