Yu et al. reported that the variant c.772 + 27 G > C in intron 6 of ACVRL1gene in a Chinese family with hereditary hemorrhagic telangiectasia (HHT) presents a decreased expression of ACVRL1 mRNA and protein in affected HHT2 patients47. The gene discussed is ACVRL1; the disease is hereditary hemorrhagic telangiectasia.