CUL4B and posterior cortical atrophy: We examined CUL4B expression in a series of PCa cell lines (DU145, LNCaP, 22RV1, VCaP, PC3 and immortalized nontumorigenic prostate epithelial cell line, RWPE) (Figure S1a), the expression of CUL4B was higher in PCa cell lines than that in RWPE cell line.