We highlight several obesity-related GWAS loci—CSK43, SLCO3A144and GNG737and GNA1535,36—and report several novel genes including LCN2, ECHS1, IDH2, and CD7. These genes also map to metabolic disease-linked pathways such as the highlighted Gαq Signaling known to have a role in adipogenesis through its action in regulating intracellular calcium levels and downstream expression of the master regulators PPARγ and C/EBPα45,46. The gene discussed is ECHS1; the disease is obesity due to melanocortin 4 receptor deficiency.