Focusing on replicated UMRs harboring lipid-CpGs (N = 16 regions) and excluding LMRs due to their small number (N = 5), TFBS linked to adipogenesis and/or obesity related metabolic-complications were enriched, with members of the STAT family24–26STAT5A27, STAT1 and STAT328 being most significant, followed by NFIB29,30 and RUNX131,32 (Supplementary Table 4). This evidence concerns the gene STAT1 and obesity disorder.