Focusing on replicated UMRs harboring lipid-CpGs (N = 16 regions) and excluding LMRs due to their small number (N = 5), TFBS linked to adipogenesis and/or obesity related metabolic-complications were enriched, with members of the STAT family24–26STAT5A27, STAT1 and STAT328 being most significant, followed by NFIB29,30 and RUNX131,32 (Supplementary Table 4). The gene discussed is SOAT1; the disease is Obesity.