CCR8 and glioblastoma: Glycans have been shown to direct EV targeting towards CCR8-positive glioblastoma cells via a triple interaction with the CCR8 ligand CCL1859, while glycans on MSC-derived EVs have been shown to direct EVs towards surface-bound sialic acid-binding immunoglobulins, such as lectin receptors, expressed on the surface of HeLa cells60.