NAT2 and peripheral neuropathy: The proposed genetic risk factors for ATDH include polymorphisms of the N-acetyltransferase 2 (NAT2) gene, which codes for the drug-metabolising enzyme, NAT2.4,5NAT2 polymorphisms may affect the activity of the NAT2 enzyme, altering the chemical modification of anti-tuberculosis drugs and their metabolites in the liver, leading to hepatic adverse reactions.6 Toxic metabolites may also cause other toxicity events, such as peripheral neuropathy and maculopapular eruption, although the majority of evidence on the pharmacogenetics of anti-tuberculosis drugs focuses on hepatotoxicity.