We further addressed the influence of microenvironment to TEG001 recognition against primary AML blasts and developed a separate PD-X model using the same p25 AML in NSG-SGM3 mice that express human cytokines (i.e. IL-3, granulocyte/macrophage colony-stimulating factor (GM-CSF), and stem cell factor (SCF)) that support better engraftment of AML blast in vivo [25]. Here, KITLG is linked to acute myeloid leukemia.