In a separate randomized clinical trial of patients with neuroblastoma, we have shown that patients with certain KIR/KIR-ligand genotypes benefited from treatment with mAb-based immunotherapy [dinutuximab (anti-GD2 mAb) + GM-CSF + interleukin-2] while patients with the opposing KIR/KIR-ligand genotype were not clinically influenced by the immunotherapy treatment [30]. This evidence concerns the gene KIR3DL1 and neuroblastoma.