BCR and chronic myelogenous leukemia, BCR-ABL1 positive: Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder characterized by the presence of [9;22] translocation and BCR/ABL fusion gene with high tyrosine kinase activity which activates MAPK pathway, cell proliferation, blocks apoptosis and leads to genome instability resulting in further development of the disease.