To determine if H-Zt/g4-MMAE is able to eliminate RON-expressing PDAC cells, Western blot analysis was performed to detect RON in tumor lysates from xenografts Levels of RON were progressively diminished in tumor lysates derived from FG cell-mediated tumors treated with H-Zt/g4-MMAE at different doses ((Additional file 1: Figure S2). The gene discussed is MST1R; the disease is neoplasm.