Subsequently, multivariate analysis showed that age (OR: 5.044; CI: 1.748–14.554, P: 0.003), gender (OR: 6.161; CI: 2.143–17.715, P: 0.001), history of cardiac stents or angina pectoris (OR: 48.813; CI: 13.674–174.246, P: 0.000), preoperative BNP (OR: 41.515; CI: 9.380–183.732, P: 0.000), surgical methods (OR: 3.357; CI: 1.026–10.983, P: 0.045), intraoperative blood transfusion (OR: 58.404; CI: 10.777–316.509, P: 0.000), as well as adhesion between lymph nodes and pericardium (OR: 3.954; CI: 1.364–11.459, P: 0.011) were the risk factors of postoperative AF (Table 2). This evidence concerns the gene NPPB and atrial fibrillation.