MUC5AC and neoplasm: Several other novel histopathological parameters are also being explored as potential prognostic biomarkers for colorectal cancer, such as tumor budding (TB), poorly differentiated clusters (PDCs), extramural vascular (vein) invasion (EMVI), perineural invasion (PNI), tumor deposits (TDs), mucin pools (MPs), and extranodal extension of nodal metastasis (ENE), but some of these are yet to be fully investigated in larger phase trials for their association with prognosis of colorectal cancer.