For instance, MALAT1 was upregulated in patients with unstable angina pectoris [45], but another study showed that MALAT1 was less expressed in atherosclerotic coronary artery plaques compared to the non-atherosclerotic internal artery, which is histopathologically similar to coronary artery in terms of structural layers but atherosclerosis-resistant [15]. Here, MALAT1 is linked to atherosclerosis.