IGHE and dengue disease: Several candidates have been studied to explore severity predictors in dengue such as vascular endothelial growth factor (VEGF), tryptase and chymase [35, 36], transforming growth factor-beta (TGF-b), and VEGF receptor-2 [9], cytokines (IL-10, IFN-γ) [8] and plasma IgE levels [11].