KCNQ1OT1 and Beckwith-Wiedemann syndrome: Analyzing KCNQ1OT1 function and its role in the development of Beckwith-Wiedemann syndrome using RNA immunoprecipitation (RIP) has shown that KCNQ1OT1 binds with PRC2 complex and DNA methyltransferase Dnmt1 [58] which leads to repression of neighboring gene transcription including Cdkn1c, Kcnq1, Slc22a18 и Phlda2.