Thus, in Alzheimer’s disease, cellular stresses lead to an increase in BACE1-AS expression, which stabilizes BACE1 mRNA and increases the level of beta-secretase this results in more amyloid plaque formation which further increases the level of BACE1-AS closing the vicious circle (Fig. 2b). The gene discussed is BACE1; the disease is early-onset autosomal dominant Alzheimer disease.