TP53 and neoplasm: Furthermore, loss of heterozygosity was observed only in the subgroup of patients with a alteration of the TP53 gene (mutations were revealed in 5 tumor samples, and promoter methylation in one tumor), which accounted for 6 (42.9%) out of 14 versus 0% in the group of 10 patients with the intact gene (р = 0.0223).