TP53 and diffuse large B-cell lymphoma: Evaluation of biological significance of all the revealed missense mutations of TP53 in our patients with DLBCL yielded the following results (Table 3): All three prognostic software tools (PolyРhen-2, SIFT and Mut_ass) classified mutations p.L130F, p.T155I, p.R196Q, p.G244S, p.V272E, and p.A276V (which lead to appearance of a functionally inactive protein) as dangerous, probably pathogenic substitutions, or substitutions with a high/moderate degree of danger.