In 1990, the IARC TP53 mutation database was created for documenting the mutations in this gene and contains information on more than 30,000 somatic and 700 germ-line mutations at present [24].Research in this database has revealed that in DLBCL, more than 120 mutations of TP53 have been described; 95% of them are single-nucleotide substitutions: 88% are missense mutations, 7% are nonsense mutations, and 5% are frame-shift mutations. The gene discussed is TP53; the disease is diffuse large B-cell lymphoma.