The proposed various mechanisms of GC effect on glucose and lipid profiles include antioxidant capacity increment [63, 64], inhibition of inflammation [48], improvement of obesity, enhanced insulin activity and sensitivity (increased glycogenesis, decreased gluconeogenesis) [62], increased expression and activity of PPARγ (improved glycemic control) [46], and inhibition of cholesterol synthesis [64]. The gene discussed is PPARG; the disease is obesity due to melanocortin 4 receptor deficiency.