When different PQ doses (0.25, 0.4 or 0.75 mg/kg) are given with ACTs, there is a greater initial fall in mean Hb concentrations in both symptomatic and asymptomatic, G6PDd malaria infected patients and G6PDd healthy individuals compared to G6PD normal (n) patients and individuals [16–22]. This evidence concerns the gene GSTM1 and malaria.