Interestingly, network analysis revealed interactions among germline and somatically mutated genes containing germline mutations with strong associations to PCa, including, KLK3, C9orf3, GLI2, KLK15, JAZF1, IRX4, NKX3–1, FGF10, RASAI, TBX5 and TERT (Fig. 4). The gene discussed is NKX3-1; the disease is posterior cortical atrophy.