The activation of the ALT mechanism has been also shown to closely correlate with the mutational status of the chromatin remodeling genes DAXX (death domain-associated protein) and ATRX (α-thalassemia/mental retardation X-linked) in different malignancies, including PanNET and pediatric glioblastoma [30, 31, 34–38]. This evidence concerns the gene GPT and thalassemia.