CD46 and hemolytic-uremic syndrome: C3c and C5b-9 complement deposition assays were performed as described previously by Noris et al. [7] Moreover, there were neither anti-complement factor H antibodies as determined by ELISA, nor mutations of atypical hemolytic uremic syndrome-related genes ADAMTS13, C3, CFB, CFB, CFH, CFHR1, CFHR2, CFHR3, CFHR4, CFHR5, CFI, DGKE, MCP/CD46, MMACHC, and THBD as detected by next-generation sequencing [8].