Taking this into account, 10 genes were selected as the best candidates for CRC germline predisposition from the approach of germline SNV/indel and somatic LOH including BRCA2, BLM, ERCC2, PARP2, RECQL, REV3L, RIF1, SEC23B, SMARCA4 and STK11IP. The gene discussed is SEC23B; the disease is colorectal carcinoma.