POLE and colorectal carcinoma: Regarding CRC, well-defined genes such as APC, MUTYH, the DNA polymerases POLE and POLD1 and the DNA mismatch repair (MMR) family (MSH2, MLH1, MSH6 and PMS2) are affected by these mutations, causing well-known hereditary syndromes (familial adenomatous polyposis, MUTYH-associated polyposis, polymerase proofreading-associated polyposis and Lynch syndrome, respectively) [5].