POU5F1 and glioblastoma: Here, we observed that the expression of different stem cell markers was reduced after GLPG1790 administration, including SOX-2, a marker necessary for the maintenance of stem cell features [55], and Oct3/4, another self-renewal regulator in stem cells in GBM [56,57], which up regulates focal adhesion kinase (FAK) and c-Src expression.