Instead, we observed deep changes in the quality of the tumour microenvironment as modifications of: (i) angiogenesis and vasculomimicry (Figure 5A–D); (ii) necrosis (Figure 5E) and hypoxia-inducible factor 2α (HIF2α) immunostaining (Figure 5F); as well as (iii) tumour infiltration by leukocytes (Figure 5G). This evidence concerns the gene EPAS1 and neoplasm.