A 2002 randomized, double-blind, controlled trial investigated the effect of CLA-trans10-cis12 on insulin sensitivity, lipid metabolism, and body composition in 60 abdominally obese men with signs of the metabolic syndrome, who were treated with 3.4 g/day CLA (isomer mixture), purified CLA-trans10-cis12, or a placebo. Here, INS is linked to metabolic syndrome.