ADRB2 and prostate neoplasm: Considering that other factors besides increased catecholamines (impaired downregulation due to the loss of BARK1, for example) may lead to activation of ADRB2 prostate tumors, analysis of biopsies for levels of catecholamines and phosphorylation of PKA substrates remains the most reliable method to identify patients with active ADRB2 pathway.