Additionally, chemokines such as CCL3/MIP-1α and CCL4/MIP-1β, and pro-inflammatory cytokines such as TNF-α, IFN-γ, IL-5, IL-10 and IL-13 are secreted in the local microenvironment and mediate various effects including recruitment of inflammatory cells to the tumor and in some cases even cell death in surrounding tumor cells [18,25,26]. The gene discussed is TNF; the disease is neoplasm.